Gene description for YWHAZ
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Gene symbol YWHAZ
Other names/aliases 14-3-3-zeta
HEL-S-3
HEL-S-93
HEL4
KCIP-1
POPCHAS
YWHAD
Species Homo sapiens
 Experiment description of studies that identified YWHAZ in Glioblastoma cells

1
Experiment ID203
Identified moleculemrna
Extracellular vesicle typeMicrovesicles
MISEVEVs
Identification method Microarray
PubMed ID 19011622   
OrganismHomo sapiens
Experiment descriptionGlioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
AuthorsSkog J, Wüer T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO
Journal name Nat Cell Biol
Publication year2008
SampleGlioblastoma cells
Sample nameGlioblastoma cells
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Flotation density-
Molecules identified in the studyProtein
miRNA
mRNA
Methods used in the studyRT-PCR
Antibody array
Microarray
EV-TRACK -

2
Experiment ID722
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 25802036   
OrganismHomo sapiens
Experiment descriptionGlioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.
Authorsde Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, Luider TM, de Witte LD, Litjens M, van Strien ME, Hol EM, Kroonen J, Robe PA, Lamfers ML, Schilham MW, Broekman ML.
Journal name Int J Cancer
Publication year2015
SampleGlioblastoma cells
Sample name U87.MG/EGFRvIII
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV150064: EV-METRIC:0%, 0%, 29%

3
Experiment ID723
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 25802036   
OrganismHomo sapiens
Experiment descriptionGlioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.
Authorsde Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, Luider TM, de Witte LD, Litjens M, van Strien ME, Hol EM, Kroonen J, Robe PA, Lamfers ML, Schilham MW, Broekman ML.
Journal name Int J Cancer
Publication year2015
SampleGlioblastoma cells
Sample nameGS184
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV150064: EV-METRIC:0%, 0%, 29%

4
Experiment ID1039
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample nameA172
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

5
Experiment ID1040
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample nameLN229
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK -

6
Experiment ID1041
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample name U87MG
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK -

7
Experiment ID1042
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample nameU251
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

8
Experiment ID1043
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample nameT98G
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

9
Experiment ID1044
Identified moleculeprotein
Extracellular vesicle typeExtracellular vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 27770278   
OrganismHomo sapiens
Experiment descriptionComprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
AuthorsMallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL.
Journal name J Neurooncol
Publication year2017
SampleGlioblastoma cells
Sample nameCCF-STTG1
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Filtration
Density gradient centrifugation
Flotation density1.09.1.11 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

10
Experiment ID1072
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 29937354   
OrganismHomo sapiens
Experiment descriptionApoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.
AuthorsPavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I.
Journal name Cancer Cell
Publication year2018
SampleGlioblastoma cells
Sample nameLethally irradiated GBM157 - apoExo - biorep2
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

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